Epigeneties: Relations to disease and laboratory findings

被引：18

作者：

Maekawa, Masato ^{[1
]}

Watanabe, Yoshihisa ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Lab Med, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan

来源：

CURRENT MEDICINAL CHEMISTRY | 2007年 / 14卷 / 25期

关键词：

epigenetics; methylation; histone deacetylation; expression; laboratory data; diagnosis; prognosis; cancer;

D O I：

10.2174/092986707782023172

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epigenetics is a postmeiotic modification of gene expression that is independent of the primary DNA sequence. DNA methylation, methylated DNA binding proteins, and historic modification-related enzymes are associated with epigenetics. Abnormalities in DNA methylation of CpG islands which are important for gene expression control, affect gene expression, which may influence carcinogenesis, aging, and other diseases. Aberrant DNA methylation occurs with aging, inflammation, viral infection, and carcinogenesis. DNA methylation can be evaluated for molecular analysis for diagnosis of early cancer. It is also important for laboratory diagnosis by using classic and authentic laboratory tests because the tests can be affected by epigenetics-controlled gene expression. It is also related to the effectiveness of therapeutic agents affecting DNA methylation and histone deacetylation, and the strategy in search of genetic abnormality for epigenetic as well as genetic error.

引用

页码：2642 / 2653

页数：12

共 191 条

[11] RNA meets chromatin [J].

Bernstein, E ;

Allis, CD .

GENES & DEVELOPMENT, 2005, 19 (14) :1635-1655

[12] THE CREATINE-CREATINE PHOSPHATE ENERGY SHUTTLE [J].

BESSMAN, SP ;

CARPENTER, CL .

ANNUAL REVIEW OF BIOCHEMISTRY, 1985, 54 :831-862

[13] DNA methylation patterns and epigenetic memory [J].

Bird, A .

GENES & DEVELOPMENT, 2002, 16 (01) :6-21

[14]

BLASCO E, 1989, EXP CELL BIOL, V57, P153

[15]

Bubeník J, 2004, INT J ONCOL, V25, P487

[16]

BURNAM MH, 1981, CLIN CHEM, V27, P1724

[17]

Cairns P, 2001, CLIN CANCER RES, V7, P2727

[18]

Chan EC, 2002, CLIN CANCER RES, V8, P3741

[19] Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer [J].

Chan, Tsun Leung ;

Yuen, Siu Tsan ;

Kong, Chi Kwan ;

Chan, Yee Wai ;

Chan, Annie S. Y. ;

Ng, Wai Fu ;

Tsui, Wai Yin ;

Lo, Michelle W. S. ;

Tam, Wing Yip ;

Li, Vivian S. W. ;

Leung, Suet Yi .

NATURE GENETICS, 2006, 38 (10) :1178-1183

[20] Function and regulation of class II transactivator in the immune system [J].

Chang, CH ;

Gourley, TS ;

Sisk, TJ .

IMMUNOLOGIC RESEARCH, 2002, 25 (02) :131-142

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