Does ghrelin level change after epileptic seizure in rats?

被引：19

作者：

Ataie, Z. ^{[2
]}

Golzar, M. G. ^{[2
]}

Babri, Sh.

Ebrahimi, H. ^{[2
]}

Mohaddes, G. ^{[1
,2
]}

机构：

[1] Tabriz Univ Med Sci, Dept Physiol, Fac Med, Neurosci Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

来源：

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 2011年 / 20卷 / 04期

关键词：

Seizure; Ghrelin; PTZ; SERUM GHRELIN; SOMATOSTATIN; SECRETION; CHILDREN; DEGRADATION; OBESTATIN; GROWTH; LEPTIN;

D O I：

10.1016/j.seizure.2011.01.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Aim: Epilepsy is one of the most common neurologic problems worldwide. A relationship between epilepsy and hormones has been demonstrated. This study was designed to investigate the effect of seizure on blood ghrelin level. Methods: Twenty male Wistar rats were divided into two groups. The control group received saline and the pentylenetetrazole (PTZ) group received a single convulsive dose (50 mg/kg) of PTZ. Thirty minutes later blood samples were collected and acylated and unacylated ghrelin levels in the plasma were assayed. Results: Acylated or active form of ghrelin decreased significantly (p < 0.05) after a PTZ-induced seizure, but the reduction of unacylated and total blood ghrelin levels failed to reach statistical significance. Conclusion: These findings may reflect that PTZ-induced epilepsy decreases AG of plasma. (C) 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

引用

页码：347 / 349

页数：3

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