Interactions of meso-tetra-(4-N-oxyethylpyridyl) porphyrin, its 3-N analog and their metallocomplexes with duplex DNA

被引：33

作者：

Dalyan, YB

Haroutiunian, SG

Ananyan, GV

Vardanyan, VI

Lando, DY

Madakyan, VN

Kazaryan, RK

Messory, L

Orioli, P

Benight, AS

机构：

[1] Yerevan State Univ, Dept Phys, Chair Mol Phys, Yerevan 375025, Armenia

[2] Belarus Natl Acad Sci, Inst Bioorgan Chem, Minsk 220141, BELARUS

[3] Yerevan State Med Univ, Chair Pharmacol Chem, Yerevan 375025, Armenia

[4] Univ Florence, Dept Chem, I-50121 Florence, Italy

[5] S Univ Illinois, Dept Chem MC 111, Chicago, IL 60607 USA

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 2001年 / 18卷 / 05期

关键词：

D O I：

10.1080/07391102.2001.10506698

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Interactions of meso-tetra-(4-N-oxyethylpyridyl) porphyrin (TOEPyP(4)), its 3-N analog (TOEPyP(3)) and their Co, Cu, Ni, Zn metallocomplexes with duplex DNA have been investigated by uv/visible absorbance and circular dichrosim spectroscopies. Results reveal the interactions of these complexes with duplex DNA are of two types. (1) External binding of duplex DNA by metalloporphyrins containing Zn and Co, and (2) Binding of duplex DNA both externally and internally (by intercalation) by porphyrins not containing metals, and metalloporphyrins containing Cu and Ni. Results indicate that (4N-oxyethylpyridyl) porphyrins intercalate more preferably in the structure of duplex DNA and have weaker external binding than 3N-porphyrins.

引用

页码：677 / 687

页数：11

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LEFT-HANDED DNA HELICES [J].