Eukaryotic DNA primase

被引：116

作者：

Arezi, B ^{[1
]}

Kuchta, RD ^{[1
]}

机构：

[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 11期

关键词：

D O I：

10.1016/S0968-0004(00)01680-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic DNA primase initiates the synthesis of all new DNA strands by synthesizing short RNA oligomers on single-stranded DNA, Additionally, primase helps couple replication and repair and is critical for telomere maintenance and, therefore, chromosome stability. in light of the many aspects of DNA metabolism in which primase is involved, understanding the unique features of the mechanism of this enzyme and how it interacts with other proteins will greatly advance our knowledge of DNA replication and repair.

引用

页码：572 / 576

页数：5

共 40 条

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