Mimicking the binding of glutamate to zinc in thermolysin and carboxypeptidase:: the synthesis of [η3-(HCO2)BpBu-t,Pr-i]ZnCl by insertion of CO2 into a B-H bond of the bis(pyrazolyl)hydroborato zinc complex [BpBu-t,Pr-i]ZnCl

被引：40

作者：

Ghosh, P ^{[1
]}

Parkin, G ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1998年 / 14期

关键词：

D O I：

10.1039/a804025g

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Insertion of CO2 into one of the B-H bonds of the bis(pyrazolyl)hydroborato complex [Bp(But,Prl)]ZnCl yields [eta(3)-(HCO2) Bp(But,Prl)]ZnCl; the carboxylate group of the generated [NNO] donor ligand mimics the glutamate residues at the active sites of thermolysin and carboxypeptidase.

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页码：2281 / 2283

页数：3

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共 41 条

[1] A TRIPOD LIGAND WITH 3 DIFFERENT LEGS AND SOME CHIRAL ZINC-COMPLEXES THEREOF [J].

ABUFARAG, A ;

VAHRENKAMP, H .

INORGANIC CHEMISTRY, 1995, 34 (12) :3279-3284

[2] A MONONUCLEAR ZINC HYDROXIDE COMPLEX STABILIZED BY A HIGHLY SUBSTITUTED TRIS(PYRAZOLY)HYDROBORATO LIGAND - ANALOGIES WITH THE ENZYME CARBONIC-ANHYDRASE [J].

ALSFASSER, R ;

TROFIMENKO, S ;

LOONEY, A ;

PARKIN, G ;

VAHRENKAMP, H .

INORGANIC CHEMISTRY, 1991, 30 (21) :4098-4100

[3]

Bertini I., 1986, PROGR INORGANIC BIOC, V1

[4] CARBOXYPEPTIDASE-A [J].

CHRISTIANSON, DW ;

LIPSCOMB, WN .

ACCOUNTS OF CHEMICAL RESEARCH, 1989, 22 (02) :62-69

[5] ZINC PROTEINS - ENZYMES, STORAGE PROTEINS, TRANSCRIPTION FACTORS, AND REPLICATION PROTEINS [J].

COLEMAN, JE .

ANNUAL REVIEW OF BIOCHEMISTRY, 1992, 61 :897-946

[6] POLYFUNCTIONAL, STRUCTURALLY DEFINED CATALYSTS FOR THE ENANTIOSELECTIVE ADDITION OF DIALKYLZINC REAGENTS TO ALDEHYDES [J].

COREY, EJ ;

YUEN, PW ;

HANNON, FJ ;

WIERDA, DA .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (03) :784-786

[7] RELATIONSHIPS BETWEEN THE CARBON-OXYGEN STRETCHING FREQUENCIES OF CARBOXYLATO COMPLEXES AND THE TYPE OF CARBOXYLATE COORDINATION [J].

DEACON, GB ;

PHILLIPS, RJ .

COORDINATION CHEMISTRY REVIEWS, 1980, 33 (03) :227-250

[8] Bis(pyrazolylethyl) ether ligation to zinc and cobalt: Meridional vs facial coordination and the suitability of such ligands in providing a NNO donor set for modeling bioinorganic aspects of zinc chemistry [J].

Dowling, C ;

Murphy, VJ ;

Parkin, G .

INORGANIC CHEMISTRY, 1996, 35 (09) :2415-2420

[9] Elaboration of the bis(pyrazolyl)hydroborato ligand [Bp(Bu-t,Pr-i)] into the NNO donor ligand, [(MeO)Bp(Bu-t,Pr-i)]: Structural characterization of a complex in which the [(MeO)Bp(Bu-t,Pr-i)] ligand models the binding of zinc to the peptide backbone in thermolysin [J].

Dowling, C ;

Parkin, G .

POLYHEDRON, 1996, 15 (14) :2463-2465

[10] Structural characterization of bis(pyrazolyl)hydroborato thallium complexes: monomeric ''two-coordinate'' thallium derivatives supplemented by [Tl-H-B] interactions [J].

Dowling, C ;

Ghosh, P ;

Parkin, G .

POLYHEDRON, 1997, 16 (19) :3469-3473

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