Metal ion homeostasis in Bacillus subtilis

被引：172

作者：

Moore, CM ^{[1
]}

Helmann, JD ^{[1
]}

机构：

[1] Cornell Univ, Dept Microbiol, Ithaca, NY 14853 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2005年 / 8卷 / 02期

关键词：

D O I：

10.1016/j.mib.2005.02.007

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacillus subtilis, a Gram-positive soil bacterium, provides a model system for the study of metal ion homeostasis. Metalloregulatory proteins serve as the arbiters of metal ion sufficiency and regulate the expression of metal homeostasis pathways. In B. subtilis, uptake systems are regulated by the highly selective metal-sensing repressors Fur (iron), Zur (zinc), and MntR (manganese). Metal efflux systems are regulated by MerR and ArsR family homologs which, by contrast, can be rather non-specific with regard to metal selectivity. A Fur homolog, PerR, functions as an Fe(II)-dependent peroxide stress sensor and regulates putative metal transport and storage functions.

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收藏

页码：188 / 195

页数：8

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共 54 条

[11] Direct inhibition by nitric oxide of the transcriptional ferric uptake regulation protein via nitrosylation of the iron [J].

D'Autréaux, B ;

Touati, D ;

Bersch, B ;

Latour, JM ;

Michaud-Soret, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (26) :16619-16624

[12] Fur functions as an activator and as a repressor of putative virulence genes in Neisseria meningitidis [J].

Delany, I ;

Rappuoli, R ;

Scarlato, V .

MOLECULAR MICROBIOLOGY, 2004, 52 (04) :1081-1090

[13] The Fur repressor controls transcription of iron-activated and -repressed genes in Helicobacter pylori [J].

Delany, I ;

Spohn, G ;

Rappuoli, R ;

Scarlato, V .

MOLECULAR MICROBIOLOGY, 2001, 42 (05) :1297-1309

[14] Transition metal speciation in the cell: Insights from the chemistry of metal ion receptors [J].

Finney, LA ;

O'Halloran, TV .

SCIENCE, 2003, 300 (5621) :931-936

[15] Recognition of DNA by three ferric uptake regulator (Fur) homologs in Bacillus subtilis [J].

Fuangthong, M ;

Helmann, JD .

JOURNAL OF BACTERIOLOGY, 2003, 185 (21) :6348-6357

[16] Regulation of the Bacillus subtilis fur and perR genes by PerR:: Not all members of the PerR regulon are peroxide inducible [J].

Fuangthong, M ;

Herbig, AF ;

Bsat, N ;

Helmann, JD .

JOURNAL OF BACTERIOLOGY, 2002, 184 (12) :3276-3286

[17] Two MerR homologues that affect copper induction of the Bacillus subtilis copZA operon [J].

Gaballa, A ;

Cao, M ;

Helmann, JD .

MICROBIOLOGY-SGM, 2003, 149 :3413-3421

[18] Bacillus subtilis CPx-type ATPases:: Characterization of Cd, Zn, Co and Cu efflux systems [J].

Gaballa, A ;

Helmann, JD .

BIOMETALS, 2003, 16 (04) :497-505

[19] A peroxide-induced zinc uptake system plays an important role in protection against oxidative stress in Bacillus subtilis [J].

Gaballa, A ;

Helmann, JD .

MOLECULAR MICROBIOLOGY, 2002, 45 (04) :997-1005

[20] Identification of a zinc-specific metalloregulatory protein, Zur, controlling zinc transport operons in Bacillus subtilis [J].

Gaballa, A ;

Helmann, JD .

JOURNAL OF BACTERIOLOGY, 1998, 180 (22) :5815-5821

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