Complementary Role of Vitamin D Deficiency and the Interleukin-28B rs12979860 C/T Polymorphism in Predicting Antiviral Response in Chronic Hepatitis C

被引：117

作者：

Bitetto, Davide ^{[1
]}

Fattovich, Giovanna ^{[2
]}

Fabris, Carlo ^{[1
]}

Ceriani, Elisa ^{[3
]}

Falleti, Edmondo ^{[1
]}

Fornasiere, Ezio ^{[1
]}

Pasino, Michela ^{[2
]}

Ieluzzi, Donatella ^{[2
]}

Cussigh, Annarosa ^{[1
]}

Cmet, Sara ^{[1
]}

Pirisi, Mario ^{[3
,4
]}

Toniutto, Pierluigi ^{[1
]}

机构：

[1] Univ Udine, Dept Med & Pathol Clin & Expt, Med Liver Transplantat Unit, I-33100 Udine, Italy

[2] Univ Verona, Gastroenterol Clin, Dept Med, Azienda Osped Univ, I-37100 Verona, Italy

[3] Univ Piemonte Orientale, Dept Clin & Expt Med, Novara, Italy

[4] Res Ctr Autoimmune Dis, Novara, Italy

来源：

HEPATOLOGY | 2011年 / 53卷 / 04期

关键词：

ALPHA-2B PLUS RIBAVIRIN; PEGINTERFERON ALPHA-2B; PEGYLATED INTERFERON; VIROLOGICAL RESPONSE; SUSTAINED RESPONSE; THERAPY;

D O I：

10.1002/hep.24201

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The widely accepted interleukin-28B (IL-28B) rs12979860 C/T polymorphism and the more recently proposed vitamin D serum concentration are two novel predictors of the response to antiviral treatment in chronic hepatitis C virus (HCV) infection. This study aimed to verify whether the IL-28B rs12979860 C/T polymorphism and pretreatment serum vitamin D levels have independent or complementary roles in predicting the rates of sustained viral response (SVR). The present study included 211 consecutive, treatment-naive chronic HCV patients who had their pretreatment serum 25-OH vitamin D level and IL-28B rs12979860 C/T genotype determined. Overall, SVR was achieved by 134/211 (63.5%) patients and by 47/110 (42.7%) patients infected with difficult-to-treat HCV genotypes. On multivariate analysis, SVR was predicted by the HCV genotype, the IL-28B rs12979860 C/T polymorphism, and gamma-glutamyl transpeptidase, HCV RNA, cholesterol, and 25-OH vitamin D serum levels, with an area under the receiver operating characteristic (ROC) curve of 0.827. When difficult-to-treat HCV genotypes were analyzed separately, the SVR was predicted by the IL-28B rs12979860 C/T polymorphism, viral load, and serum vitamin D level, with an area under the ROC curve of 0.836. Moreover, by categorizing these latter patients into four groups-C/C homozygotes with vitamin D levels > 20 ng/mL (group A) or <= 20 ng/mL (group B) and C/T heterozygotes or T/T homozygotes with vitamin D levels > 20 ng/mL (group C) or <= 20 ng/mL (group D)-a significant linear trend was observed, with SVR rates in the following descending order: group A, 18/21 (85.7%); group B, 6/11 (54.5%); group C, 14/38 (36.8%); and group D, 9/40 (22.5%) (P < 0.0001). Conclusion: Vitamin D serum levels are complementary to the IL-28B rs12979860 C/T polymorphism in enhancing the correct prediction of the SVR in treatment-naive chronic hepatitis C. (HEPATOLOGY 2011;53:1118-1126)

引用

页码：1118 / 1126

页数：9