A flexible and positively charged PNA analogue with an ethylene-linker to the nucleobase: Synthesis and hybridization properties

被引：43

作者：

Hyrup, B

Egholm, M

Buchardt, O

Nielsen, PE

机构：

[1] UNIV COPENHAGEN, PANUM INST, DEPT BIOCHEM A, DK-2200 COPENHAGEN N, DENMARK

[2] UNIV COPENHAGEN, DEPT CHEM, CTR BIOMOL RECOGNIT, DK-2100 COPENHAGEN O, DENMARK

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 10期

关键词：

D O I：

10.1016/0960-894X(96)00176-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The positively charged and relatively flexible PNA unit ethT (Fig. 1) has an ethylene linker between backbone and nucleobase rather than the methylene carbonyl linker normally present in PNA. The synthesis of the corresponding modified monomer, its incorporation into PNA oligomers, and their hybridization properties to DNA are described. (C) 1996 Elsevier Science Ltd

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页码：1083 / 1088

页数：6

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