Disulfiram effects on acute cocaine administration

被引:82
作者
McCance-Katz, EF [1 ]
Kosten, TR
Jatlow, P
机构
[1] Yale Psychiat Inst, New Haven, CT USA
[2] Gen Clin Res Ctr, New Haven, CT USA
[3] Connecticut Mental Hlth Ctr, Subst Abuse Treatment Unit, New Haven, CT USA
[4] 116A VA Connecticut Healthcare Syst, Dept Psychiat, West Haven, CT 06516 USA
[5] Yale Univ, Dept Lab Med, New Haven, CT 06520 USA
[6] Yale Univ, Sch Med, New Haven, CT 06520 USA
关键词
cocaine; alcohol; disulfiram; drug interaction; pharmacotherapy; humans;
D O I
10.1016/S0376-8716(98)00050-7
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Disulfiram (Antabuse) is being used in outpatient clinical trials to determine its efficacy as a treatment for cocaine dependence. This inpatient randomized, double-blind, placebo-controlled, within-subjects study was conducted to determine whether disulfiram (placebo, 250 or 500 mg/day) alters responses to acute intranasal cocaine (placebo, 1 or 2 mg/kg) administration. Effects of disulfiram on cocaine pharmacokinetics, physiological, and behavioral responses were determined. Disulfiram treatment increased plasma cocaine concentrations three to six times and significantly increased cocaine-associated cardiovascular responses, but did not significantly alter behavioral responses to cocaine. These interactions should be considered in the decision regarding disulfiram treatment in cocaine dependent patients. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:27 / 39
页数:13
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