Identification of a neuronal cell surface molecule, plexin, in mice

被引：35

作者：

Kameyama, T ^{[1
]}

Murakami, Y ^{[1
]}

Suto, F ^{[1
]}

Kawakami, A ^{[1
]}

Takagi, S ^{[1
]}

Hirata, T ^{[1
]}

Fujisawa, H ^{[1
]}

机构：

[1] NAGOYA UNIV,GRAD SCH SCI,DIV BIOL SCI,DEV BIOL LAB,GRP DEV NEUROBIOL,CHIKUSA KU,NAGOYA,AICHI 46401,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 226卷 / 02期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

D O I：

10.1006/bbrc.1996.1388

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We searched for mouse homologues of the cell adhesion protein plexin which was originally found in Xenopus, and obtained a cDNA encoding a plexin-like protein. We referred to this protein as mouse plexin 1. The overall amino acid identity between mouse plexin 1 and Xenopus plexin was 84%. As in the Xenopus plexin, the extracellular segment of mouse plexin 1 protein possessed three cysteine-rich domains which showed significant homology with the cysteine-rich domain of the c-Met proto-oncogene protein product (c-Met protein) and Met-like receptor protein tyrosine kinases. Northern blot analysis indicated that mouse plexin 1 was predominantly expressed in the brain. (C) 1996 Academic Press, Inc.

引用

页码：524 / 529

页数：6

共 23 条

[1]

IDENTIFICATION OF THE HEPATOCYTE GROWTH-FACTOR RECEPTOR AS THE C-MET PROTOONCOGENE PRODUCT [J].