Origin of antiphospholipid antibodies: induction of aPL by viral peptides

被引：45

作者：

Gharavi, AE ^{[1
]}

Pierangeli, SS ^{[1
]}

机构：

[1] Morehouse Sch Med, Dept Med, Atlanta, GA 30310 USA

来源：

LUPUS | 1998年 / 7卷

关键词：

viral peptides; antiphospholipid antibodies; antiphospholipid syndrome; lupus anticoagulant; cytomegalovirus; adenovirus;

D O I：

10.1177/096120339800700213

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The clinical associations of antiphospholipid antibodies (aPL) are well recognized but the mechanism(s) causing the production of these antibodies are not yet known. We demonstrated the induction of pathogenic aPL antibodies that caused intrauterine fetal death and transverse myelopathy due to spinal cord infarction in mice by immunization with foreign beta(2)GPI. We also induced aPL and anti-beta(2)-GPI in mice by immunization with PL-binding viral peptides and hypothesized that in APS patients, aPL may be induced by beta(2)GPI-like-PL-binding products of common human bacteria and viruses.

引用

页码：S52 / S54

页数：3

共 25 条

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