Molecular pathology of non-small-cell lung cancer

被引：44

作者：

Breuer, RHJ ^{[1
]}

Postmus, PE ^{[1
]}

Smit, EF ^{[1
]}

机构：

[1] Free Univ Amsterdam, Med Ctr, Dept Pulmonol, NL-1007 MB Amsterdam, Netherlands

来源：

RESPIRATION | 2005年 / 72卷 / 03期

关键词：

carcinogenesis; lung cancer; molecular pathology; non-small-cell lung cancer; oncogenes; tumor suppressor genes;

D O I：

10.1159/000085376

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The molecular basis of lung carcinogenesis must be understood more fully and exploited to enhance survival rates of patients suffering from lung cancer. In this review we will discuss the major molecular alterations that occur in lung cancer. Emphasis is placed on alterations that occur early during carcinogenesis since they might be relevant for future screening programs. Finally we will shortly review new approaches that are used to study the molecular pathology of lung cancer and how they can be applied in a clinical setting. Copyright (C) 2005 S. Karger AG, Basel.

引用

页码：313 / 330

页数：18

共 205 条

[91]

Kurie JM, 2000, CLIN CANCER RES, V6, P2973

[92] Vascular endothelial growth factor increases release of gelatinase a and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro [J].

Lamoreaux, WJ ;

Fitzgerald, MEC ;

Reiner, A ;

Hasty, KA ;

Charles, ST .

MICROVASCULAR RESEARCH, 1998, 55 (01) :29-42

[93] Aberrant methylation of the CDKN2A/P16INK4A gene promoter region in preinvasive bronchial lesions:: A prospective study in high-risk patients without invasive cancer [J].

Lamy, A ;

Sesboüé, R ;

Bourguignon, J ;

Dautréaux, B ;

Métayer, J ;

Frébourg, T ;

Thiberville, L .

INTERNATIONAL JOURNAL OF CANCER, 2002, 100 (02) :189-193

[94] Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines [J].

Lantuéjoul, S ;

Constantin, B ;

Drabkin, H ;

Brambilla, C ;

Roche, J ;

Brambilla, E .

JOURNAL OF PATHOLOGY, 2003, 200 (03) :336-347

[95] MULTIPLICITY GENERATES DIVERSITY IN THE RETINOIC ACID SIGNALING PATHWAYS [J].

LEID, M ;

KASTNER, P ;

CHAMBON, P .

TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (10) :427-433

[96]

Lenferink AEG, 2001, CANCER RES, V61, P6583

[97] Comparative proteomics analysis of human lung squamous carcinoma [J].

Li, C ;

Chen, ZC ;

Xiao, ZQ ;

Wu, XY ;

Zhan, XQ ;

Zhang, XP ;

Li, MY ;

Li, JL ;

Feng, XP ;

Liang, SP ;

Chen, P ;

Xie, JY .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 309 (01) :253-260

[98]

Li DH, 2001, CANCER RES, V61, P1445

[99] PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer [J].

Li, J ;

Yen, C ;

Liaw, D ;

Podsypanina, K ;

Bose, S ;

Wang, SI ;

Puc, J ;

Miliaresis, C ;

Rodgers, L ;

McCombie, R ;

Bigner, SH ;

Giovanella, BC ;

Ittmann, M ;

Tycko, B ;

Hibshoosh, H ;

Wigler, MH ;

Parsons, R .

SCIENCE, 1997, 275 (5308) :1943-1947

[100]

LI ZH, 1994, AM J PATHOL, V144, P303

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