Developmental biology - SMAD proteins and mammalian anatomy

被引：30

作者：

Derynck, R ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Growth & Dev, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Anat, Program Cell Biol & Dev Biol, San Francisco, CA 94143 USA

来源：

NATURE | 1998年 / 393卷 / 6687期

关键词：

D O I：

10.1038/31593

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Members of the transforming growth factor-β (TGF-β) family, which signal through SMAD proteins, are involved in many developmental processes. Inactivation of the genes encoding two of the SMAD proteins, Smads 2 and 4, shows that both are required to lay down some of the primary layers of the animal body. Smad2 also seems to act in anterior-posterior patterning and the development of left-right asymmetry.

引用

页码：737 / 739

页数：3

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