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Cytogenetic effects of lambda-cyhalothrin on Wistar rat bone marrow

被引：67
作者：
Çelik, A
Mazmanci, B
Çamlica, Y
Askin, A
Çömelekoglu, Ü
机构：
[1] Mersin Univ, Dept Biol, Fac Sci & Art, TR-33342 Mersin, Turkey
[2] Mersin Univ, Dept Biophys, Fac Med, Mersin, Turkey
来源：
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2003年 / 539卷 / 1-2期
关键词：
lambda-cyhalothrin; structural chromosomal aberrations; pyrethroid insecticide; micronucleus formation; polychromatic erythrocytes; Wistar rat;
D O I：
10.1016/S1383-5718(03)00159-1
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];
摘要：
In this study, the genotoxic and cytotoxic potential of lambda-cyhalothrin (LCT), a synthetic pyrethroid insecticide, was investigated in Wistar rat bone-marrow cells, using the structural chromosomal aberration (SCA) and micronucleus (MN) test systems. LCT was administrated to adult female albino rats as repeated i.p. doses of 6.12, 3.06, 0.8 mg/kg BW for 13 days at 48 h intervals. Mitomycin C (MMC) was used as a positive control (2 mg/kg BW). All the doses of LCT increased the number of structural chromosomal aberrations and the frequency of micronucleated erythrocytes, compared with the control group. It was also observed that LCT caused a significant decrease in the number of polychromatic erythrocytes. Our results demonstrate that LCT has a clastogenic/genotoxic potential as measured by the bone marrow SCA and MN tests in Wistar rats. (C) 2003 Elsevier B.V. All rights reserved.
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收藏
页码：91 / 97
页数：7
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