Drug resistant Plasmodium falciparum in an area of seasonal transmission

被引:29
作者
Babiker, HA
Satti, G
Ferguson, H
Bayoumi, R
Walliker, D
机构
[1] Univ Edinburgh, Sch Biol Sci, Edinburgh EH9 3JT, Midlothian, Scotland
[2] Sultan Qaboos Univ, Fac Med, Dept Biochem, Al Khoud, Oman
[3] Univ Khartoum, Fac Med, Dept Biochem, Khartoum, Sudan
关键词
chloroquine resistance; Plasmodium falciparum; genetic diversity; seasonal transmission; fitness;
D O I
10.1016/j.actatropica.2005.04.007
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Eastern Sudan ties at the edge of the malaria endemicity stratum, where transmission intensity is low and seasonal. The main malaria parasite in the region, Plasmodium falciparum, survives the Iona dry and transmission-free season as asymptomatic sub-patent infections, and resurges following annual rains. The short-lived annual transmission in this area precipitates cyclical malaria epidemics among the semi-immune inhabitants who resort to excessive anti-malarial drugs usage at this time of the year. Chloroquine resistance (CQR) first emerged in this area in the mid 1980s; however, subsequent surveys demonstrated that the rate of parasitological failure to CQ remained stable over a period of 8 years (1986-1993). Nevertheless, the CQR level varied between years in association with the amount of annual rain. Detailed molecular surveys revealed significant temporal fluctuations in the frequency of resistant P. falciparum genotypes, increasing during the dry season but dwindling at the start of the next transmission season. The pattern of spread of drug resistance in the area is discussed in the context of parasite biology and malaria epidemiology of this region. (c) 2005 Published by Elsevier B.V.
引用
收藏
页码:260 / 268
页数:9
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