Asymmetric organocatalytic oxy-Michael addition of alcohols to α,β-unsaturated aldehydes

被引：49

作者：

Kano, Taichi ^{[1
]}

Tanaka, Youhei ^{[1
]}

Maruoka, Keiji ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Kyoto 6068502, Japan

来源：

TETRAHEDRON | 2007年 / 63卷 / 35期

基金：

日本学术振兴会;

关键词：

oxy-michael addition; alpha; beta-unsaturated aldehyde; organocatalyst; iminium catalysis;

D O I：

10.1016/j.tet.2007.03.179

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A 1,4-addition of alcohols to alpha,beta-unsaturated aldehydes was found to be efficiently promoted by biphenyldiamine-based catalyst 3 without formation of the acetals. An asymmetric variant of this reaction has also been performed by designing a novel axially chiral organo-catalyst (R)-10c. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：8658 / 8664

页数：7

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