Enantioselective organocatalytic conjugate addition of N heterocycles to α,β-unsaturated aldehydes

被引：168

作者：

Diner, Peter ^{[1
]}

Nielsen, Martin ^{[1
]}

Marigo, Mauro ^{[1
]}

Jorgensen, Karl Anker ^{[1
]}

机构：

[1] Aarhus Univ, Dept Chem, Ctr Catalysis, Danish Natl Res Fdn, DK-8000 Aarhus C, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 12期

关键词：

aldehydes; asymmetric synthesis; density functional calculations; nitrogen heterocycles; organocatalysis;

D O I：

10.1002/anie.200604854

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Must love cats.! Chiral amines catalyze the enantioselective addition of N-heterocyclic compounds to α,β- unsaturated compounds in high yields and with enantioselectivities of up to 94% ee (see scheme; TMS = trimethylsilyl). The intermediates and transition states for the catalytic cycle were identified by performing DFT calculations. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1983 / 1987

页数：5

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