Steroidal saponins from the underground parts of Ruscus aculeatus and their cytostatic activity on HL-60 cells

被引：44

作者：

Mimaki, Y ^{[1
]}

Kuroda, M ^{[1
]}

Kameyama, A ^{[1
]}

Yokosuka, A ^{[1
]}

Sashida, Y ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

来源：

PHYTOCHEMISTRY | 1998年 / 48卷 / 03期

关键词：

Ruscus aculeatus; Liliaceae; underground parts; steroidal saponins; spirostanol saponins; furostanol saponins; cytostatic activity; HL-60; cells;

D O I：

10.1016/S0031-9422(98)00036-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Phytochemical examination of the underground parts of Ruscus aculeatus has been undertaken as part of a systematic study of plants of the Liliaceae. Six new spirostanol saponins and five new furostanol saponins were isolated, and their structures were assigned on the basis of spectroscopic analysis, including two-dimensional NMR techniques, and hydrolysis. Ruscogenin diglycoside with three acetyl groups attached to the inner galactosyl moiety and its corresponding 26-glucosyloxyfurostanol saponin showed cytostatic activity on leukemia HL-60 cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：485 / 493

页数：9

共 15 条

[1]

C-13 NMR SPECTRAL INVESTIGATIONS .10. C-13 NMR-SPECTROSCOPY OF STEROIDAL SAPOGENINS AND STEROIDAL SAPONINS [J].