The elusive function of metallothioneins

被引：567

作者：

Palmiter, RD

机构：

[1] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA

[2] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 15期

关键词：

D O I：

10.1073/pnas.95.15.8428

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Biochemistry and genetics are both required to elucidate the function of macromolecules. There is no question that metallothioneins (MTs) have unique biochemical properties, but genetic experiments have not substantiated the importance of MTs under physiological conditions. Even after thousands of studies describing the structure, biochemical characteristics, tissue distribution, induction, and consequences of genetic disruption and deliberate overexpression, the evolutionary forces that led to the initial appearance, gene duplications, and nearly ubiquitous expression of MTs remain enigmatic.

引用

页码：8428 / 8430

页数：3

共 58 条

[11]

Erickson JC, 1997, J NEUROSCI, V17, P1271

[12] METALLOTHIONEIN [J].

HAMER, DH .

ANNUAL REVIEW OF BIOCHEMISTRY, 1986, 55 :913-951

[13] CADMIUM-RESISTANT VARIANT OF THE CHINESE-HAMSTER (CHO) CELL WITH INCREASED METALLOTHIONEIN INDUCTION CAPACITY [J].

HILDEBRAND, CE ;

TOBEY, RA ;

CAMPBELL, EW ;

ENGER, MD .

EXPERIMENTAL CELL RESEARCH, 1979, 124 (02) :237-246

[14] Control of zinc transfer between thionein, metallothionein, and zinc proteins [J].

Jacob, C ;

Maret, W ;

Vallee, BL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3489-3494

[15] The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase [J].

Jiang, LJ ;

Maret, W ;

Vallee, BL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3483-3488

[16]

KAGI JHR, 1993, ADV LIF SCI, P29

[17] EXPRESSION AND REGULATION OF A HUMAN METALLOTHIONEIN GENE CARRIED ON AN AUTONOMOUSLY REPLICATING SHUTTLE VECTOR [J].

KARIN, M ;

CATHALA, G ;

NGUYENHUU, MC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (13) :4040-4044

[18] METALLOTHIONEINS - PROTEINS IN SEARCH OF FUNCTION [J].

KARIN, M .

CELL, 1985, 41 (01) :9-10

[19]

Kelly EJ, 1996, J NUTR, V126, P1782

[20] A murine model of Menkes disease reveals a physiological function of metallothionein [J].

Kelly, EJ ;

Palmiter, RD .

NATURE GENETICS, 1996, 13 (02) :219-222

← 1 2 3 4 5 6 →