Lipase-catalyzed kinetic resolution of large secondary alcohols having tetraphenylporphyrin

被引：24

作者：

Ema, T ^{[1
]}

Jittani, M ^{[1
]}

Sakai, T ^{[1
]}

Utaka, M ^{[1
]}

机构：

[1] Okayama Univ, Fac Engn, Dept Appl Chem, Okayama 7008530, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(98)01338-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Large secondary alcohols, 5-[4-(1-hydroxyethyl)phenyl]-10,15,20-triphenylporphyrin (1a) and the zinc complex 1b, designed on the basis of the transition-state model recently proposed by us, were subjected to the lipase-catalyzed transesterifications. The alcohols were resolved using lipases from Pseudomonas cepacia (lipase PS), Candida antarctica (CHIRAZYME L-2), Rhizomucor miehei (CHIRAZYME L-9), and Pseudomonas aeruginosa (lipase LIP) with high enantioselectivities (E > 100). (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6311 / 6314

页数：4

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