Synthesis of ent-19-nortestosterone from its naturally occurring antipode

被引：9

作者：

Teerhuis, NM ^{[1
]}

Huisman, IAM ^{[1
]}

Groen, MB ^{[1
]}

机构：

[1] NV Organon, Res & Dev, NL-5340 BH Oss, Netherlands

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(01)00296-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of ent-19-nortestosterone from natural 19-nortestosterone is described. The synthetic sequence takes advantage of the 'near symmetry' properties of the steroid; removal/introduction of a methyl group and conversion of the A- into the D-ring and vice versa eventually results in overall inversion of the stereochemistry. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：2869 / 2871

页数：3

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