Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells

被引:53
作者
Dirks, Peter B. [1 ,2 ]
机构
[1] Univ Toronto, Hosp Sick Children, Div Neurosurg, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Hosp Sick Children, Program Dev Biol, Toronto, ON M5G 1X8, Canada
关键词
brain tumour; neural stem cell; cancer stem cell; hierarchy; self-renewal;
D O I
10.1098/rstb.2006.2017
中图分类号
Q [生物科学];
学科分类号
07 [理学]; 0710 [生物学]; 09 [农学];
摘要
Conceptual and technical advances in neural stem cell biology are being applied to the study of human brain tumours. These studies suggest that human brain tumours are organized as a hierarchy and are maintained by a small number of tumour cells that have stem cell properties. Most of the bulk population of human brain tumours comprise cells that have lost the ability to initiate and maintain tumour growth. Although the cell of origin for human brain tumours is uncertain, recent evidence points towards the brain's known proliferative zones. The identification of brain tumour stem cells has important implications for understanding brain tumour biology and these cells may be critical cellular targets for curative therapy.
引用
收藏
页码:139 / 152
页数:14
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