A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p

被引：102

作者：

Posthuma, D

Luciano, M

de Geus, EJC

Wright, MJ

Slagboom, PE

Montgomery, GW

Boomsma, DI

Martin, NG

机构：

[1] Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands

[2] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

[3] Leiden Univ, Med Ctr, Dept Mol Epidemiol, Leiden, Netherlands

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2005年 / 77卷 / 02期

关键词：

D O I：

10.1086/432647

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Between 40% and 80% of the variation in human intelligence ( IQ) is attributable to genetic factors. Except for many rare mutations resulting in severe cognitive dysfunction, attempts to identify these factors have not been successful. We report a genomewide linkage scan involving 634 sibling pairs designed to identify chromosomal regions that explain variation in IQ. Model-free multipoint linkage analysis revealed evidence of a significant quantitative-trait locus for performance IQ at 2q24.1-31.1 (LOD score 4.42), which overlaps the 2q21-33 region that has repeatedly shown linkage to autism. A second region revealed suggestive linkage for both full-scale and verbal IQs on 6p25.3-22.3 ( LOD score 3.20 for full-scale IQ and 2.33 for verbal IQ), overlapping marginally with the 6p22.3-21.31 region implicated in reading disability and dyslexia.

引用

收藏

页码：318 / 326

页数：9

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