Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia

被引：32

作者：

Bolonna, AA ^{[1
]}

Kerwin, RW ^{[1
]}

Munro, J ^{[1
]}

Arranz, MJ ^{[1
]}

Makoff, AJ ^{[1
]}

机构：

[1] Inst Psychiat, Sect Clin Neuropharmacol, Dept Med Psychol, London SE5 8AF, England

来源：

SCHIZOPHRENIA RESEARCH | 2001年 / 47卷 / 01期

基金：

英国医学研究理事会;

关键词：

metabotropic glutamate receptor; schizophrenia;

D O I：

10.1016/S0920-9964(99)00235-2

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

A dysfunctional glutamatergic system has been implicated in the pathophysiology of schizophrenia. The group III metabotropic glutamate receptor (mGluR) types 7 acid 8 presynaptically inhibit glutamate release, thereby modulating glutamatergic transmission in the brain. We conducted association studies to investigate the novel Tyr433Phe (mGluR7) variant and the 2846-C/T (mGluR8) polymorphism in schizophrenia. Both variants, present at high frequencies, failed to demonstrate any significant association with schizophrenia (mGluR7 [Tyr433Phe] allele: P = 0.33: genotype: P = 0.63; mGluR8 [2846-C/T] allele: P = 0.72; genotype: P = 0.63). (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：99 / 103

页数：5

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