Synthesis and solid state structure of a hydrazone-disulfide macrocycle and its dynamic covalent ring-opening under acidic and basic conditions

被引：13

作者：

von Delius, Max ^{[1
]}

Geertsema, Edzard M. ^{[1
]}

Leigh, David A. ^{[1
]}

Slawin, Alexandra M. Z. ^{[2
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

[2] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 20期

基金：

欧洲研究理事会; 英国工程与自然科学研究理事会;

关键词：

COMBINATORIAL LIBRARIES; CHEMISTRY; EXCHANGE; SYSTEMS; INTERPLAY; KINETICS;

D O I：

10.1039/c0ob00214c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and characterisation, including solid state structure, of a macrocycle containing both a hydrazone and a disulfide linkage is described. Selective ring-opening of the macrocycle under thermodynamic control could be achieved at either the disulfide or the hydrazone linkage by applying mutually exclusive sets of reaction conditions.

引用

页码：4617 / 4624

页数：8

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