Recent advances in the study of hsp90 structure and mechanism of action

被引:73
作者
Toft, DO [1 ]
机构
[1] Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
关键词
D O I
10.1016/S1043-2760(98)00060-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The 90 kDa heat shock protein, hsp90, is a major molecular chaperone of the cell that appears to have particular significance to cellular regulatory processes. New tools and approaches have revealed a number of target proteins for hsp90, most of which ave protein kinases or transcription factors. While the mechanism of action of hsp90 is not well understood reasonable models have emerged describing some functional domains of this protein, the importance of conformational transitions for its activity and its role within a multi-component chaperoning pathway of the cell.
引用
收藏
页码:238 / 243
页数:6
相关论文
共 59 条
  • [31] Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: Regulation of HSP90-binding activity of FKBP52
    Miyata, Y
    Chambraud, B
    Radanyi, C
    Leclerc, J
    Lebeau, MC
    Renoir, JM
    Shirai, R
    Catelli, MG
    Yahara, I
    Baulieu, EE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (26) : 14500 - 14505
  • [32] NADEAU K, 1993, J BIOL CHEM, V268, P1479
  • [33] In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone
    Nathan, DF
    Vos, MH
    Lindquist, S
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (24) : 12949 - 12956
  • [34] MECHANISM OF DIMER FORMATION OF THE 90-KDA HEAT-SHOCK PROTEIN
    NEMOTO, T
    OHARANEMOTO, Y
    OTA, M
    TAKAGI, T
    YOKOYAMA, K
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 233 (01): : 1 - 8
  • [35] A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains
    OwensGrillo, JK
    Czar, MJ
    Hutchison, KA
    Hoffman, K
    Perdew, GH
    Pratt, WB
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (23) : 13468 - 13475
  • [36] LOCALIZATION AND CHARACTERIZATION OF THE 86-KDA AND 84-KDA HEAT-SHOCK PROTEINS IN HEPA 1C1C7 CELLS
    PERDEW, GH
    HORD, N
    HOLLENBACK, CE
    WELSH, MJ
    [J]. EXPERIMENTAL CELL RESEARCH, 1993, 209 (02) : 350 - 356
  • [37] PICARD D, 1997, MOL BIOL STEROID NUC, P1
  • [38] Studies with purified chaperones advance the understanding of the mechanism of glucocorticoid receptor hsp90 heterocomplex assembly
    Pratt, WB
    Dittmar, KD
    [J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1998, 9 (06) : 244 - 252
  • [39] Steroid receptor interactions with heat shock protein and immunophilin chaperones
    Pratt, WB
    Toft, DO
    [J]. ENDOCRINE REVIEWS, 1997, 18 (03) : 306 - 360
  • [40] Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
    Prodromou, C
    Roe, SM
    OBrien, R
    Ladbury, JE
    Piper, PW
    Pearl, LH
    [J]. CELL, 1997, 90 (01) : 65 - 75