Potent Inhibition of HIV-1 Entry with a Chemically Programmed Antibody Aided by an Efficient Organocatalytic Synthesis

被引：19

作者：

Gavrilyuk, Julia ^{[1
,2
,3
]}

Uehara, Hisatoshi ^{[1
,2
,3
]}

Otsubo, Nobumasa ^{[1
,2
,3
]}

Hessell, Ann ^{[4
]}

Burton, Dennis R. ^{[4
]}

Barbas, Carlos F., III ^{[1
,2
,3
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

来源：

CHEMBIOCHEM | 2010年 / 11卷 / 15期

关键词：

anti-HIV antibody; asymmetric synthesis; CCR5; inhibition; neutralizing antibody; organocatalysis; ALPHA-AMINO-ACIDS; CLICK CHEMISTRY; CATALYTIC ANTIBODIES; ALDOLASE ANTIBODY; REACTIVE IMMUNIZATION; CCR5; ANTAGONISTS; TYPE-1; ACTIVATION; MECHANISM; RECEPTOR;

D O I：

10.1002/cbic.201000432

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：2113 / 2118

页数：6

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