Biodegradable polymers for microencapsulation of drugs

被引：211

作者：

Park, JH ^{[1
]}

Ye, ML ^{[1
]}

Park, K ^{[1
]}

机构：

[1] Purdue Univ, Dept Pharmaceut & Biomed Engn, W Lafayette, IN 47907 USA

来源：

MOLECULES | 2005年 / 10卷 / 01期

关键词：

microencapsulation technology; biodegradable polymer; drug delivery system;

D O I：

10.3390/10010146

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Drug delivery has become increasingly important mainly due to the awareness of the difficulties associated with a variety of old and new drugs. Of the many polymeric drug delivery systems, biodegradable polymers have been used widely as drug delivery systems because of their biocompatibility and biodegradability. The majority of biodegradable polymers have been used in the form of microparticles, from which the incorporated drug is released to the environment in a controlled manner. The factors responsible for controlling the drug release rate are physicochemical properties of drugs, degradation rate of polymers, and the morphology and size of microparticles. This review discusses the conventional and recent technologies for microencapsulation of the drugs using biodegradable polymers. In addition, this review presents characteristics and degradation behaviors of biodegradable polymers which are currently used in drug delivery.

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页码：146 / 161

页数：16

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