Application of click chemistry on preparation of separation materials for liquid chromatography

被引：214

作者：

Chu, Changhu ^{[1
]}

Liu, Renhua ^{[1
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

来源：

CHEMICAL SOCIETY REVIEWS | 2011年 / 40卷 / 05期

基金：

国家高技术研究发展计划(863计划);

关键词：

CHIRAL STATIONARY-PHASE; HYDROPHILIC-INTERACTION CHROMATOGRAPHY; AZIDE-ALKYNE CYCLOADDITION; OLIGO(ETHYLENE GLYCOL); EFFICIENT STRATEGY; SILICA-GELS; ENRICHMENT; GLYCOPEPTIDES; PEPTIDES; FACILE;

D O I：

10.1039/c0cs00066c

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

With the increasing requirement for analysis and separation of samples related to genomics, proteomics, metabolomics, pharmacology and agrochemistry, diverse stationary phases for liquid chromatography have been prepared by Cu(I)-catalyzed 1, 3-dipolar azide-alkyne cycloaddition reaction (CuAAC). It has been proved that CuAAC is a powerful tool for preparing covalently bonded stationary phases. In this tutorial review, we highlighted the preparation of separation materials by immobilization of functional groups on silica beads, polymer beads and agarose via CuAAC and their applications in liquid chromatography and related purposes, such as separation of polar compounds, enrichment of valuable bio-samples, orthogonal two-dimensional HPLC and chiral separation. Meanwhile, agarose-based separation materials for affinity chromatography are reviewed.

引用

页码：2177 / 2188

页数：12

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