Preparation of novel chiral stationary phase based on click chemistry for ligand exchange chromatography

被引：8

作者：

Fu, Chun Mei ^{[1
]}

Shi, Hong Yu ^{[2
,3
]}

Qian, Guang Sheng ^{[1
]}

Li, Zhang Wan ^{[1
]}

机构：

[1] Sichuan Univ, W China Sch Pharm, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2009年 / 20卷 / 11期

关键词：

Click chemistry; Ligand exchange chromatography; Chiral stationary phase; DL-amino acids; LIQUID-CHROMATOGRAPHY; SEPARATION;

D O I：

10.1016/j.cclet.2009.05.011

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Click chemistry was applied to immobilize L-proline derivative onto azide-modified silica gel to give a novel chiral stationary phase (denoted as click-CSP) for ligand exchange chromatography. The developed protocol combines the benefits of operational simplicity, exceptionally mild conditions and high surface loadings. The enantioselectivity alpha Of Some DL-amino acids on the click-CSP were found to be in the range from 1.13 to 3.46. The chromatographic resolutions of some DL-amino acids and the stability study firmly illustrate the potential of click chemistry for preparation chiral stationary phase for ligand exchange chromatography. (c) 2009 Zhang Wan Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：1345 / 1347

页数：3

共 15 条

[1]

CuI-catalyzed alkyne-azide "click" cycloadditions from a mechanistic and synthetic perspective [J].