ESCRT Machinery and Cytokinesis: the Road to Daughter Cell Separation

被引:77
作者
Caballe, Anna [1 ]
Martin-Serrano, Juan [1 ]
机构
[1] Kings Coll London, Sch Med, Guys Hosp, Dept Infect Dis, London SE1 9RT, England
基金
英国惠康基金; 英国医学研究理事会;
关键词
abscission; cytokinesis; ESCRT; midbody; retroviral budding; MEDIATED ABSCISSION CHECKPOINT; LATE-BUDDING DOMAINS; STRUCTURAL BASIS; CLEAVAGE FURROW; PROTEIN CHMP1B; III COMPLEX; MEMBRANE; MIDBODY; RECRUITMENT; DIVISION;
D O I
10.1111/j.1600-0854.2011.01244.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The endosomal sorting complex required for transport (ESCRT) machinery is a set of cellular protein complexes required for at least three topologically equivalent membrane scission events, namely multivesicular body (MVB) formation, retroviral particle release and midbody abscission during cytokinesis. Recently, several studies have explored the mechanism by which the core ESCRT-III subunits mediate membrane scission and might be differentially required according to the functions of the pathway. In this review, we discuss the links between the ESCRT machinery and cytokinesis, with special focus on abscission initiation and regulation.
引用
收藏
页码:1318 / 1326
页数:9
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