The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression

被引：143

作者：

Houthuijzen, J. M. ^{[1
]}

Daenen, L. G. M. ^{[1
]}

Roodhart, J. M. L. ^{[1
]}

Voest, E. E. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Med Oncol, NL-3508 GA Utrecht, Netherlands

来源：

BRITISH JOURNAL OF CANCER | 2012年 / 106卷 / 12期

关键词：

mesenchymal stem cells; tumour progression; drug resistance; chemotherapy resistance; ENDOTHELIAL-CELLS; LEUKEMIA CELLS; APOPTOSIS; MICROENVIRONMENT; METABOLISM; SURVIVAL; STROMA; ACID;

D O I：

10.1038/bjc.2012.201

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

It is becoming increasingly clear that the tumour microenvironment has a very important role in tumour progression and drug resistance. Many different cell types within the tumour stroma have an effect on tumour progression either in a positive or in a negative way. Mesenchymal stem cells (MSCs) are a distinct population of cells that have been linked with tumour growth. Mesenchymal stem cells can home to tumours where they modulate the immune system and facilitate tumour growth, angiogenesis and metastasis. Recent studies have shown that MSCs also have an important role in the resistance to various anti-cancer drugs. This mini-review provides an overview of the functional properties of MSCs in tumour progression and drug resistance. British Journal of Cancer (2012) 106, 1901-1906. doi:10.1038/bjc.2012.201 www.bjcancer.com Published online 17 May 2012 (C) 2012 Cancer Research UK

引用

页码：1901 / 1906

页数：6

共 30 条

[1]

Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells [J].

Balakrishnan, Kumudha ;

Burger, Jan A. ;

Quiroga, Maite P. ;

Henneberg, Marina ;

Ayres, Mary L. ;

Wierda, William G. ;

Gandhi, Varsha .

BLOOD, 2010, 116 (07) :1083-1091

[2]

Increased Number of Mesenchymal Stem Cell-like Cells in Peripheral Blood of Patients with Bone Sarcomas [J].

Bian, Zhen-Yu ;

Li, Gang ;

Gan, Yao-Kai ;

Hao, Yong-Qiang ;

Xu, Wen-Ting ;

Tang, Ting-Ting .

ARCHIVES OF MEDICAL RESEARCH, 2009, 40 (03) :163-168

[3]

Mesenchymal stem cells in immunoregulation [J].

Chen, Xi ;

Armstrong, Marilyn Ann ;

Li, Gang .

IMMUNOLOGY AND CELL BIOLOGY, 2006, 84 (05) :413-421

[4]

Dawson MR, 2011, AM J CANCER RES, V1, P144

[5]

Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis [J].

Hung, Shih-Chieh ;

Pochampally, Radhika R. ;

Chen, Sy-Chi ;

Hsu, Shu-Ching ;

Prockop, Darwin J. .

STEM CELLS, 2007, 25 (09) :2363-2370

[6]

Purification of stearidonic acid (18:4(n-3)) and hexadecatetraenoic acid (16:4(n-3)) from algal fatty acid with lipase and medium pressure liquid chromatography [J].

Ishihara, K ;

Murata, M ;

Kaneniwa, M ;

Saito, H ;

Komatsu, W ;

Shinohara, K .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2000, 64 (11) :2454-2457

[7]

Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase [J].

Iwamoto, Shotaro ;

Mihara, Keichiro ;

Downing, James R. ;

Pui, Ching-Hon ;

Campana, Dario .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (04) :1049-1057

[8]

CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells [J].

Jin, Linhua ;

Tabe, Yoko ;

Konoplev, Sergej ;

Xu, Yuanyuan ;

Leysath, Clinton E. ;

Lu, Hongbo ;

Kimura, Shinya ;

Ohsaka, Akimichi ;

Rios, Mary-Beth ;

Calvert, Leslie ;

Kantarjian, Hagop ;

Andreeff, Michael ;

Konopleva, Marina .

MOLECULAR CANCER THERAPEUTICS, 2008, 7 (01) :48-58

[9]

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis [J].

Karnoub, Antoine E. ;

Dash, Ajeeta B. ;

Vo, Annie P. ;

Sullivan, Andrew ;

Brooks, Mary W. ;

Bell, George W. ;

Richardson, Andrea L. ;

Polyak, Kornelia ;

Tubo, Ross ;

Weinberg, Robert A. .

NATURE, 2007, 449 (7162) :557-U4

[10]

Gene Therapy Using TRAIL-Secreting Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells against Intracranial Glioma [J].

Kim, Seong Muk ;

Lim, Jung Yeon ;

Park, Sang In ;

Jeong, Chang Hyun ;

Oh, Ji Hyeon ;

Jeong, Moonsup ;

Oh, Wonil ;

Park, Sang-Hoon ;

Sung, Young-Chul ;

Jeun, Sin-Soo .

CANCER RESEARCH, 2008, 68 (23) :9614-9623

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