The Conformation and CETP Inhibitory Activity of [10]-Dehydrogingerdione Isolated from Zingiber officinale

被引：23

作者：

Choi, Soon-Yong ^{[2
]}

Park, Gil-Soon ^{[3
]}

Lee, Sung Yoon ^{[1
]}

Kim, Ji Yeon ^{[1
]}

Kim, Young Kook ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Immune Modulator Res Ctr, Ochang Eup 363883, Cheongwon Gun, South Korea

[2] Hannam Univ, Dept Biotechnol, Taejon 305811, South Korea

[3] Natl Forens Serv, Forens DNA Ctr, Seoul 158707, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2011年 / 34卷 / 05期

关键词：

Cholesteryl ester transfer protein; Gingiber officinale; Inhibitor; ESTER TRANSFER PROTEIN; GINGER; MECHANISM; DISEASE;

D O I：

10.1007/s12272-011-0505-5

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

In the course of searching for cholesteryl ester transfer protein (CETP) inhibitors from natural sources, a new type of CETP inhibitor, [10]-dehydrogingerdione (1), was isolated from the extract of rhizomes of Zingiber officinale Roscoe. By NMR spectroscopic analysis of its (1)H-NMR, (13)C-NMR, and (1)H-(1)H COSY, HMBC, HMQC and NOESY, more precise structure, compared with its originally proposed structures, of [10]-dehydrogingerdione has been elucidated. This active compound inhibited human plasma CETP with IC(50) values of 35 mu M.

引用

页码：727 / 731

页数：5

共 17 条

[1]

Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research [J].

Ali, Badreldin H. ;

Blunden, Gerald ;

Tanira, Musbah O. ;

Nemmar, Abderrahim .

FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (02) :409-420

[2]

CHOLESTERYL ESTER TRANSFER PROTEIN - ITS ROLE IN PLASMA-LIPID TRANSPORT [J].

BARTER, P ;

RYE, KA .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1994, 21 (09) :663-672

[3]

Targeting cholesteryl ester transfer protein for the prevention and management of cardiovascular disease [J].

Barter, PJ ;

Kastelein, JJP .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (03) :492-499

[4]

6-Dehydrogingerdione Sensitizes Human Hepatoblastoma Hep G2 Cells to TRAIL-Induced Apoptosis via Reactive Oxygen Species-Mediated Increase of DR5 [J].

Chen, Chung-Yi ;

Tai, Cheng-Jeng ;

Cheng, Jiin-Tsuey ;

Zheng, Juan-Juan ;

Chen, Ying-Zong ;

Liu, Tsan-Zon ;

Yiin, Shuenn-Jiun ;

Chern, Chi-Liang .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, 58 (09) :5604-5611

[5]

Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of action [J].

Clark, RW ;

Ruggeri, RB ;

Cunningham, D ;

Bamberger, MJ .

JOURNAL OF LIPID RESEARCH, 2006, 47 (03) :537-552

[6]

WIEDENDIOL-A AND WIEDENDIOL-B, CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS FROM THE MARINE SPONGE XESTOSPONGLIA-WIEDENMAYERI [J].

COVAL, SJ ;

CONOVER, MA ;

MIERZWA, R ;

KING, A ;

PUAR, MS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (06) :605-610

[7]

Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans - A randomized phase II dose-response study [J].

de Grooth, GJ ;

Kuivenhoven, JA ;

Stalenhoef, AFH ;

de Graaf, J ;

Zwinderman, AH ;

Posma, JL ;

van Tol, A ;

Kastelein, JJP .

CIRCULATION, 2002, 105 (18) :2159-2165

[8]

Ginger - An herbal medicinal product with broad anti-inflammatory actions [J].

Grzanna, R ;

Lindmark, L ;

Frondoza, CG .

JOURNAL OF MEDICINAL FOOD, 2005, 8 (02) :125-132

[9]

Jagetia G, 2004, CANCER BIOTHER RADIO, V19, P422, DOI 10.1089/cbr.2004.19.422

[10]

CETP inhibitory activity of ceramides, isolated from the gorgonian Acabaria undulata [J].

Jeong, TS ;

Ahn, JA ;

Kim, YK ;

Bok, SH ;

Kwon, BM ;

Shin, J ;

Seo, Y .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (11) :1481-1482

← 1 2 →