Destroying retroviruses from within

被引：16

作者：

Boeke, JD

Hahn, B

机构：

[1] UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294

[2] UNIV ALABAMA,DEPT MICROBIOL,BIRMINGHAM,AL 35294

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 11期

关键词：

D O I：

10.1016/0966-842X(96)10065-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One strategy for neutralizing retroviral infectivity is to induce the incorporation of lethal fusion proteins, such as capsid protein-nuclease fusions, into the virion during the normal viral assembly process. Genes encoding such antiviral fusion proteins must be nontoxic to the host, lethal to the virus, and must be efficiently delivered to, and expressed in, appropriate target cells.

引用

收藏

页码：421 / 426

页数：6

相关论文

共 27 条

[11]

KEWALRAMANI VN, 1996, IN PRESS VIROLOGY, V218

[12] LOCALIZATION OF VIRAL PROTEIN-X IN SIMIAN IMMUNODEFICIENCY VIRUS MACAQUE STRAIN AND ANALYSIS OF ITS PACKAGING REQUIREMENTS [J].

LISKA, V ;

SPEHNER, D ;

MEHTALI, M ;

SCHMITT, D ;

KIRN, A ;

AUBERTIN, AM .

JOURNAL OF GENERAL VIROLOGY, 1994, 75 :2955-2962

[13] THE VIF PROTEIN OF HUMAN AND SIMIAN IMMUNODEFICIENCY VIRUSES IS PACKAGED INTO VIRIONS AND ASSOCIATES WITH VIRAL CORE STRUCTURES [J].

LIU, HM ;

WU, XY ;

NEWMAN, M ;

SHAW, GM ;

HAHN, BH ;

KAPPES, JC .

JOURNAL OF VIROLOGY, 1995, 69 (12) :7630-7638

[14] Escherichia coli RNase HI inhibits murine leukaemia virus reverse transcription in vitro and yeast retrotransposon Ty1 transposition in vivo [J].

Ma, WP ;

Crouch, RJ .

GENES TO CELLS, 1996, 1 (06) :581-593

[15] NEW ANTIVIRAL STRATEGY USING CAPSID NUCLEASE FUSION PROTEINS [J].

NATSOULIS, G ;

BOEKE, JD .

NATURE, 1991, 352 (6336) :632-635

[16] TARGETING OF A NUCLEASE TO MURINE LEUKEMIA-VIRUS CAPSIDS INHIBITS VIRAL MULTIPLICATION [J].

NATSOULIS, G ;

SESHAIAH, P ;

FEDERSPIEL, MJ ;

REIN, A ;

HUGHES, SH ;

BOEKE, JD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (02) :364-368

[17] HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time [J].

Perelson, AS ;

Neumann, AU ;

Markowitz, M ;

Leonard, JM ;

Ho, DD .

SCIENCE, 1996, 271 (5255) :1582-1586

[18] TARGETING OF CHROLAMPHENICOL ACETYLTRANSFERASE TO HUMAN-IMMUNODEFICIENCY-VIRUS PARTICLES VIA VPR AND VPX [J].

SATO, A ;

ISAKA, Y ;

KODAMA, M ;

YOSHIMOTO, J ;

KAWAUCHI, S ;

KUWATA, T ;

ADACHI, A ;

HAYAMI, M ;

YOSHIE, O ;

FUJIWARA, T .

MICROBIOLOGY AND IMMUNOLOGY, 1995, 39 (12) :1015-1019

[19] Therapeutic effect of Gag-nuclease fusion protein on retrovirus-infected cell cultures [J].

Schumann, G ;

Qin, L ;

Rein, A ;

Natsoulis, G ;

Boeke, JD .

JOURNAL OF VIROLOGY, 1996, 70 (07) :4329-4337

[20] DISTINCT RNA SEQUENCES IN THE GAG REGION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 DECREASE RNA STABILITY AND INHIBIT EXPRESSION IN THE ABSENCE OF REV PROTEIN [J].

SCHWARTZ, S ;

FELBER, BK ;

PAVLAKIS, GN .

JOURNAL OF VIROLOGY, 1992, 66 (01) :150-159