Gastrointestinal satiety signals

被引：120

作者：

Chaudhri, Owais B. ^{[1
]}

Salem, Victoria ^{[1
]}

Murphy, Kevin G. ^{[1
]}

Bloom, Stephen R. ^{[1
]}

机构：

[1] Hammersmith Hosp, Imperial Coll London, Dept Metab Med, London W12 0NN, England

来源：

ANNUAL REVIEW OF PHYSIOLOGY | 2008年 / 70卷

基金：

英国医学研究理事会;

关键词：

pancreatic polypeptide; peptide YY; glucagon-like peptide-1; oxyntomodulin; cholecystokinin; vagus nerve;

D O I：

10.1146/annurev.physiol.70.113006.100506

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The increasing prevalence of obesity worldwide has imparted renewed impetus to the study of the mechanisms of appetite regulation. Digestion and nutrient absorption take place in the gastrointestinal (GI) tract, whereas food intake is controlled by neuronal circuits in the central nervous system. The need for gut-brain cross talk is therefore clear. It is now recognized that hormones released into the circulation from the GI tract in response to nutritional stimuli form a key component of this gut-brain axis. Peptides such as glucagon-like peptide-1, oxyntomodulin, pancreatic polypeptide, and peptide YY3-36 reduce food intake in both animal models and in humans. Physiologically, such peptides are thought to act as satiety signals and meal terminators. Here, we review the current state of the field of the effects of gut hormone action on appetite control.

引用

页码：239 / 255

页数：17

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