Infectious agents associated with schizophrenia: A meta-analysis

被引:172
作者
Arias, Isabel [2 ]
Sorlozano, Antonio [1 ]
Villegas, Enrique [1 ]
de Dios Luna, Juan [3 ]
McKenney, Kathryn [4 ,5 ]
Cervilla, Jorge [4 ,5 ,6 ]
Gutierrez, Blanca [4 ,5 ]
Gutierrez, Jose [1 ,7 ]
机构
[1] Univ Granada, Dept Microbiol, Sch Med, E-18012 Granada, Spain
[2] Inst Catala Salut, CAP El Clot, Barcelona, Spain
[3] Univ Granada, Dept Stat & Operat Res, E-18012 Granada, Spain
[4] Univ Granada, Inst Neurosci, Dept Psychiat, E-18012 Granada, Spain
[5] Univ Granada, CIBERSAM, E-18012 Granada, Spain
[6] San Cecilio Univ Hosp, Mental Hlth Unit, Granada, Spain
[7] Virgen de las Nieves Univ Hosp, Microbiol Serv, Granada, Spain
关键词
Schizophrenia; Infection; Meta-analysis; BORNA-DISEASE-VIRUS; HERPES-SIMPLEX-VIRUS; POLYMERASE-CHAIN-REACTION; NUCLEIC-ACID SEQUENCES; BLOOD MONONUCLEAR-CELLS; CENTRAL-NERVOUS-SYSTEM; MENTAL-HEALTH WORKERS; EPSTEIN-BARR VIRUS; TOXOPLASMA-GONDII; PRENATAL EXPOSURE;
D O I
10.1016/j.schres.2011.10.026
中图分类号
R749 [精神病学];
学科分类号
100204 [神经病学];
摘要
Schizophrenia is a highly disabling and limiting disorder for patients and the possibility that infections by some microorganisms may be associated to its development may allow prevention and recovery. In the current study we have done a meta-analysis of studies that have assessed the possible association between detection of different infectious agents and schizophrenia. We report results that support the idea that there is a statistically significant association between schizophrenia and infection by Human Herpesvirus 2 (OR=1.34; CI 95%: 1.09-1.70; p=0.05), Borna Disease Virus (OR=2.03; CI 95%: 1.35-3.06; p<0.01), Human Endogenous Retrovirus W (OR=19.31; CI 95%: 6.74-55.29; p<0.001), Chlamydophila pneumoniae (OR=6.34; CI 95%: 2.83-14.19; p<0.001), Chlamydophila psittaci (OR=29.05; CI 95%: 8.91-94.70; p<0.001) and Toxoplasma gondii (OR=2.70; CI 95%: 1.34-4.42; p=0.005). The implications of these findings are discussed and further research options are also explicated. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:128 / 136
页数:9
相关论文
共 114 条
[1]
ALBRECHT P, 1980, LANCET, V2, P769
[2]
ALEXANDER RC, 1992, ARCH GEN PSYCHIAT, V49, P47
[3]
SEARCH FOR EVIDENCE OF HERPES-SIMPLEX VIRUS, TYPE-1, OR VARICELLA-ZOSTER VIRUS-INFECTION IN POSTMORTEM BRAIN-TISSUE FROM SCHIZOPHRENIC-PATIENTS [J].
ALEXANDER, RC ;
CABIRAC, G ;
LOWENKOPF, T ;
CASANOVA, MF ;
KLEINMAN, J ;
WYATT, RJ ;
KIRCH, DG .
ACTA PSYCHIATRICA SCANDINAVICA, 1992, 86 (05) :418-420
[4]
Seroepidemiology of Toxoplasma gondii infection in psychiatric inpatients in a northern Mexican city [J].
Alvarado-Esquivel, Cosme ;
Alanis-Quinones, Olga-Patricia ;
Arreola-Valenzuela, Miguel-Angel ;
Rodriguez-Briones, Alfredo ;
Piedra-Nevarez, Luis-Jorge ;
Duran-Morales, Ehecatl ;
Estrada-Martinez, Sergio ;
Martinez-Garcia, Sergio-Arturo ;
Liesenfeld, Oliver .
BMC INFECTIOUS DISEASES, 2006, 6 (1)
[5]
Causal association between cannabis and psychosis: examination of the evidence [J].
Arseneault, L ;
Cannon, M ;
Witton, J ;
Murray, RM .
BRITISH JOURNAL OF PSYCHIATRY, 2004, 184 :110-117
[6]
BARR CE, 1990, ARCH GEN PSYCHIAT, V47, P869
[7]
OPERATING CHARACTERISTICS OF A BANK CORRELATION TEST FOR PUBLICATION BIAS [J].
BEGG, CB ;
MAZUMDAR, M .
BIOMETRICS, 1994, 50 (04) :1088-1101
[8]
Evolution of human endogenous retroviral sequences: a conceptual account [J].
Blikstad, V. ;
Benachenhou, F. ;
Sperber, G. O. ;
Blomberg, J. .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2008, 65 (21) :3348-3365
[9]
Toxoplasma gondii as a risk factor for early-onset schizophrenia:: Analysis of filter paper blood samples obtained at birth [J].
Bo Mortensen, Preben ;
Norgaard-Pedersen, Bent ;
Waltoft, Berit Lindum ;
Sorensen, Tina L. ;
Hougaard, David ;
Torrey, E. Fuller ;
Yolken, Robert H. .
BIOLOGICAL PSYCHIATRY, 2007, 61 (05) :688-693
[10]
Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies - the key marker triplet determining infection and prevailing in severe mood disorders [J].
Bode, L ;
Reckwald, P ;
Severus, WE ;
Stoyloff, R ;
Ferszt, R ;
Dietrich, DE ;
Ludwig, H .
MOLECULAR PSYCHIATRY, 2001, 6 (04) :481-491