GC-MS and HPLC-MS analysis of bioactive pharmaceuticals and personal-care products in environmental matrices

被引：152

作者：

Hao, Chunyan ^{[1
]}

Zhao, Xiaoming ^{[1
]}

Yang, Paul ^{[1
]}

机构：

[1] Ontario Minist Environm, Lab Serv Branch, Appl Chromatography Sect, Etobiocke, ON M9P 3V6, Canada

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2007年 / 26卷 / 06期

关键词：

chromatography; detection limit; mass spectrometry; matrix effect; pharmaceuticals and personal-care products; PPCPs; QA; QC; quality assurance; quality control;

D O I：

10.1016/j.trac.2007.02.011

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We review analytical methods published between January 2001 and January 2007 using either gas chromatography (GC) or highperformance liquid chromatography (HPLC) separations and mass spectrometric (MS) detection technologies for the analysis of bioactive pharmaceuticals and personal-care products (PPCPs) in environmental matrices. We emphasize sample preparation, the pros and cons of available MS techniques, the benefits of using quality control and quality assurance (QC/QA) protocols during routine analysis, and the difficulties associated with the matrix effect in the electrospray ionization (ESI) source. We discuss the need for a concerted approach to determine numerical values associated with limits of detection in this emerging area of environmental analysis, along with the use of QC/QA samples and low-level data qualifiers with recommended solutions. Crown Copyright (C) 2007 Published by Elsevier Ltd. All rights reserved.

引用

收藏

页码：569 / 580

页数：12

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