Resistant starch attenuates colonic DNA damage induced by higher dietary protein in rats

被引：79

作者：

Toden, S

Bird, AR

Topping, DL

Conlon, MA

机构：

[1] CSIRO, Hlth Sci & Nutr, Adelaide, SA 5000, Australia

[2] Univ Adelaide, Sch Mol & Biomed Sci, Discipline Physiol, Adelaide, SA 5005, Australia

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2005年 / 51卷 / 01期

关键词：

D O I：

10.1207/s15327914nc5101_7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidemiologic studies suggest that dietary complex carbohydrates are protective against colorectal cancer but dietary protein may increase risk. However, experimental data to support these relationships are scant. We have shown in rats that consumption of a high-protein (25% casein) diet for 4 wk resulted in a twofold increase in damage to colonocyte DNA compared with a low-protein (15% casein) diet. This was associated with thinning of the colonic mucous barrier and increased levels of fecal p-cresol. Addition of resistant starch as a high- amylose maize starch to the diet increased cecal short-chain fatty acid pools and attenuated DNA damage, suggesting protection against genotoxic agents. In humans, this could translate to altered risk of colonic cancer.

引用

页码：45 / 51

页数：7

共 25 条

[1] Potential of short chain fatty acids to modulate the induction of DNA damage and changes in the intracellular calcium concentration by oxidative stress in isolated rat distal colon cells [J].