Myo-inositol in depressive and healthy subjects determined by frontal 1H-magnetic resonance spectroscopy at 1.5 tesla

被引:74
作者
Frey, R [1 ]
Metzler, D
Fischer, P
Heiden, A
Scharfetter, J
Moser, E
Kasper, S
机构
[1] Univ Hosp Vienna, Dept Gen Psychiat, A-1090 Vienna, Austria
[2] Univ Vienna, Inst Med Phys, NMR Grp, Vienna, Austria
[3] Univ Hosp Vienna, Clin MR Unit, Vienna, Austria
关键词
myo-inositol; H-1-magnetic resonance spectroscopy; depression; antidepressive medication;
D O I
10.1016/S0022-3956(98)00033-8
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Myo-inositol (mI) as a precursor in the phosphatidylinositol second messenger system has been reported to be reduced in depression. By means of proton-magnetic resonance spectroscopy (H-1-MRS) the mi levels in the frontal brain were investigated in vivo in the present study. Twenty-two patients (mean age: 42.8 +/- 10.7 years) with depressive episodes according to ICD 10 (HAMD score > 17) were compared to 22 healthy subjects (28.0 +/- 5.3 years). Two voxels (30 x 20 x 20 mm(3)) in the frontal lobes were examined in a Siemens Magnetom SP 4000 at 1.5 T (STEAM sequence: TR = 3500 ms, TE = 55 ms). With the total creatine (Cr) as an internal standard, mI/Cr ratios were calculated to follow the mi levels. In the left frontal lobe, mI/Cr was 0.43 +/- 0.06 in depressive patients and 0.46 +/- 0.07 in healthy subjects; concerning the right frontal lobe, mI/Cr was 0.46 +/- 0.08 and 0.48 +/- 0.06, respectively. There were neither significant differences between the two groups nor between the hemispheres. Since there was a significant positive correlation (R = 0.6) between the age and the mI/Cr in the right frontal lobe of depressed patients, age matched pairs analysis was performed (n = 2 x 10, in each group: nine females, one male, < 40 years). In the right frontal lobe, the patients' mI/Cr of 0.40 +/- 0.05 was now significantly lower than the controls' mI/Cr of 0.45+/-0.06. However, most of the patients were on antidepressive medication. Interestingly, it was exactly this group of patients which showed significantly lower mi levels. We regard our investigation as a pilot study which suggests an influence of age and antidepressants on mi levels and should be taken into consideration in further investigations in depressive patients. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:411 / 420
页数:10
相关论文
共 45 条
[1]  
BARABAN JM, 1989, AM J PSYCHIAT, V146, P1251
[2]  
BARKAI IA, 1978, BIOL PSYCHIAT, V13, P65
[3]  
BELMAKER RH, 1995, ADV BIOCHEM PSYCHOPH, V49, P67
[4]  
*BELTZ TEST GMBH, 1986, COLL INT PSYCH SCAL
[5]   INOSITOL PHOSPHATES AND CELL SIGNALING [J].
BERRIDGE, MJ ;
IRVINE, RF .
NATURE, 1989, 341 (6239) :197-205
[6]  
Brand A, 1997, CELL MOL BIOL, V43, P645
[7]   In vivo proton magnetic resonance spectroscopy of the normal aging human brain [J].
Chang, L ;
Ernst, T ;
Poland, RE ;
Jenden, DJ .
LIFE SCIENCES, 1996, 58 (22) :2049-2056
[8]   THE CONCENTRATION OF N-ACETYL ASPARTATE, CREATINE PLUS PHOSPHOCREATINE, AND CHOLINE IN DIFFERENT PARTS OF THE BRAIN IN ADULTHOOD AND SENIUM [J].
CHRISTIANSEN, P ;
TOFT, P ;
LARSSON, HBW ;
STUBGAARD, M ;
HENRIKSEN, O .
MAGNETIC RESONANCE IMAGING, 1993, 11 (06) :799-806
[9]  
DEICKEN RF, 1995, AM J PSYCHIAT, V152, P915
[10]   LOCALIZED HIGH-RESOLUTION PROTON NMR-SPECTROSCOPY USING STIMULATED ECHOES - INITIAL APPLICATIONS TO HUMAN-BRAIN INVIVO [J].
FRAHM, J ;
BRUHN, H ;
GYNGELL, ML ;
MERBOLDT, KD ;
HANICKE, W ;
SAUTER, R .
MAGNETIC RESONANCE IN MEDICINE, 1989, 9 (01) :79-93