Enantioselective access to 2,7-cis-disubstituted oxepanes:: Formal synthesis of (+)-isolaurepan

被引：36

作者：

Carreño, MC ^{[1
]}

Mazery, RD

Urbano, A

Colobert, F

Solladié, G

机构：

[1] Univ Autonoma Madrid, Dept Quim Organ, Madrid 28049, Spain

[2] Univ Strasbourg 1, CNRS, Lab Stereochim Associe, F-67087 Strasbourg 2, France

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 02期

关键词：

D O I：

10.1021/ol036299i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The asymmetric synthesis of 2,7-cis-disubstituted oxepanes bearing a sulfoxide is achieved from commercially available precursors in only five steps. The key step is the highly diastereoselective Et3SiH/TMSOTf-promoted reductive cyclization of enantiopure hydroxysulfinyl aryl or alkyl ketones.

引用

页码：297 / 299

页数：3

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