G proteins in development

被引：126

作者：

Malbon, CC ^{[1
]}

机构：

[1] SUNY Stony Brook, Sch Med, Hlth Sci Ctr, Dept Pharmacol, Stony Brook, NY 11794 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1716

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The focus of developmental biologists has expanded from the analysis of gene expression to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate signalling from a superfamily of heptahelical receptors (G-protein-coupled receptors) to a smaller number of effector units that include adenylyl cyclases, phospholipase C and various ion channels. The convergence of developmental biology with cell signalling has now revealed overlaps in which G proteins mediate complex pathways in embryonic development.

引用

页码：689 / 701

页数：13

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