Chromatographic study of terpene derivatives on porous graphitic carbon stationary phase with β-cyclodextrin as mobile phase modifier

被引：34

作者：

Clarot, I ^{[1
]}

Cledat, D ^{[1
]}

Battu, S ^{[1
]}

Cardot, PJP ^{[1
]}

机构：

[1] Univ Limoges, Lab Chim Analyt & Bromatol, Fac Pharm, F-87025 Limoges, France

来源：

JOURNAL OF CHROMATOGRAPHY A | 2000年 / 903卷 / 1-2期

关键词：

stationary phases; LC; porous graphitic carbon; mobile phase composition; inclusion complexes; cyclodextrins; alpha-terpineol; thymol; geraniol; linalool;

D O I：

10.1016/S0021-9673(00)00907-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The stoichiometric coefficients and apparent formation constants (K-f) of alpha -terpineol, thymol, geraniol and linalool complexes with beta -cyclodextrin (beta -CD) were determined using HPLC with a porous graphitic carbon (PGC) chromatographic support. Measurements were performed with four different methanol-water mobile phases. All the terpene derivatives under study form 1:1 guest-CD complexes. Graphs of K-f as a function of the mobile phase composition appeared different from those classically described for RP-C-18 and suggest that the PGC stationary phase could play an active role in the complexation process. Solute-CD inclusion and solute-stationary phase interactions may be involved in this specific behavior. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：67 / 76

页数：10

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