Intracellular signaling following myocardial stretch:: an autocrine/paracrine loop

被引：32

作者：

Cingolani, HE ^{[1
]}

Pérez, NG ^{[1
]}

Aiello, EA ^{[1
]}

de Hurtado, MCC ^{[1
]}

机构：

[1] Natl Univ La Plata, Fac Ciencias Med, Ctr Invest Cardiovasc, RA-1900 La Plata, Argentina

来源：

REGULATORY PEPTIDES | 2005年 / 128卷 / 03期

关键词：

Na+/H+ exchanger; angiotensin II; endothelin; NPCa2+ exchanger;

D O I：

10.1016/j.regpep.2004.12.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The stretch of adult papillary muscle elicits a chain of autocrine/paracrine events in which the Na+/H+ exchanger (NHE-1) activation is the central step. This activation is induced by a sequential angiotensin II-endothelin (Ang II-ET) release and results in an increase in intracellular Na+ (Na-i(+)) without significant changes in intracellular pH. The increase in Nai+ negatively shifts the reverse potential of the Na+/Ca2+ exchanger (NCX) thus inducing cell Ca2+ influx that augments myocardial contractility. This increase in force represents the mechanical counterpart of the autocrine/paracrine mechanism triggered by stretch and has been called the slow force response (SFR) to stretch. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：211 / 220

页数：10

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