Novel 'Nano in Nano' Composites for Sustained Drug Delivery: Biodegradable Nanoparticles Encapsulated into Nanofiber Non-Wovens

被引：57

作者：

Beck-Broichsitter, Moritz ^{[2
,3
]}

Thieme, Marcel ^{[1
,4
]}

Nguyen, Juliane ^{[3
]}

Schmehl, Thomas ^{[2
]}

Gessler, Tobias ^{[2
]}

Seeger, Werner ^{[2
]}

Agarwal, Seema ^{[1
,4
]}

Greiner, Andreas ^{[1
,4
]}

Kissel, Thomas ^{[3
]}

机构：

[1] Univ Marburg, Dept Chem, D-35032 Marburg, Germany

[2] Univ Giessen, Dept Internal Med, Med Clin 2, D-35392 Giessen, Germany

[3] Univ Marburg, Dept Pharmaceut & Biopharm, D-35037 Marburg, Germany

[4] Univ Marburg, Sci Ctr Mat Sci, D-35032 Marburg, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2010年 / 10卷 / 12期

关键词：

biodegradable; composite materials; controlled drug delivery; nanoparticles; nanofiber non-wovens; CONTROLLED-RELEASE; ELECTROSPUN; FIBERS; SODIUM; PLGA; HYDROCHLORIDE; PROGRESS; CELLS; MATS; PLA;

D O I：

10.1002/mabi.201000100

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Novel 'nano in nano' composites consisting of biodegradable polymer nanoparticles incorporated into polymer nanofibers may efficiently modulate drug delivery. This is shown here using a combination of model compound-loaded biodegradable nanoparticles encapsulated in electrospun fibers. The dye coumarin 6 is used as model compound for a drug in order to simulate drug release from loaded poly(lactide-co-glycolide) nanoparticles. Dye release from the nanoparticles occurs immediately in aqueous solution. Dye-loaded nanoparticles which are encapsulated by electrospun polymer nanofibers display a significantly retarded release.

引用

页码：1527 / 1535

页数：9

共 34 条

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Electrospinning of Manmade and Biopolymer Nanofibers-Progress in Techniques, Materials, and Applications [J].