Mammalian Polycomb group genes are categorized as a new type of early response gene induced by B-cell receptor cross-linking

被引：14

作者：

Hasegawa, M

Tetsu, O

Kanno, R

Inoue, H

Ishihara, H

Kamiyasu, M

Taniguchi, M

Kanno, M

机构：

[1] Chiba Univ, Sch Med, Ctr BioMed Sci, Div Mol Immunol,Chuo Ku, Chiba 2608670, Japan

[2] Chiba Univ, Sch Med, Japan Sci & Technol Corp, CREST,Chuo Ku, Chiba 2608670, Japan

[3] Hiroshima Univ, Sch Med, Dept Immunol & Parasitol, Minami Ku, Hiroshima 7348551, Japan

来源：

MOLECULAR IMMUNOLOGY | 1998年 / 35卷 / 09期

关键词：

D O I：

10.1016/S0161-5890(98)00048-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polycomb group (PcG) genes were initially described in Drosophila melanogaster as regulators of the homeobox gene. Four mammalian homologues, mel-18, bmi-l, M33 and rae-28, are analyzed in this study. They not only regulate mammalian homeotic genes by analogy with their Drosophila counterparts, but also have some influence on the growth and differentiation of B lymphocytes. Here we report that these four mammalian PcG genes are rapidly induced after antigen-receptor cross-linking in B cells. Thus we would like to propose that mammalian PcG genes can be categorized as a new type of immediate early gene. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：559 / 563

页数：5

共 27 条

[1] The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors [J].