Thrombomodulin

被引：210

作者：

Weiler, H ^{[1
]}

Isermann, BH ^{[1
]}

机构：

[1] Blood Ctr SE Wisconsin Inc, Blood Res Inst, Milwaukee, WI 53226 USA

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2003年 / 1卷 / 07期

关键词：

inflammation; placenta; thrombomodulin; thrombosis;

D O I：

10.1046/j.1538-7836.2003.00306.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since its discovery as a critical cofactor in the initiation of the protein C (PC) anticoagulant pathway [1,2], biochemical and structural investigations, combined with in vivo analyses of genetically engineered mice have revealed new, and in part PC- and thrombin-independent aspects of thrombomodulin (TM) function in fibrinolysis and inflammation, and in embryogenesis. This review summarizes more recent structural and functional investigations of TM, gives an overview of the association of TM gene polymorphisms with human disease, and provides a synopsis of what is know about TM function in disease states of thrombosis, stroke, arteriosclerosis, and cancer. Newly emerging aspects of TM function in inflammation and embryogenesis are presented and discussed in detail.

引用

页码：1515 / 1524

页数：10

共 145 条

[1]

AOKI Y, 1994, THROMB HAEMOSTASIS, V71, P452

[2] Thrombin activatable fibrinolysis inhibitor and an antifibrinolytic pathway [J].

Bajzar, L .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (12) :2511-2518

[3] Structure of the fifth EGF-like domain of thrombomodulin: An EGF-like domain with a novel disulfide-bonding pattern [J].

Benitez, BAS ;

Hunter, MJ ;

Meininger, DP ;

Komives, EA .

JOURNAL OF MOLECULAR BIOLOGY, 1997, 273 (04) :913-926

[4] Relationship between endothelial cell markers and arterial stenosis in peripheral and carotid artery disease [J].

Blann, AD ;

Farrell, A ;

Picton, A ;

McCollum, CN .

THROMBOSIS RESEARCH, 2000, 97 (04) :209-216

[5]

Boehme MWJ, 1996, IMMUNOLOGY, V87, P134

[6]

BOFFA MC, 1991, NOUV REV FR HEMATOL, V33, P423

[7]

BOURIN MC, 1990, J BIOL CHEM, V265, P15424

[8] FUNCTIONAL DOMAINS OF RABBIT THROMBOMODULIN [J].

BOURIN, MC ;

BOFFA, MC ;

BJORK, I ;

LINDAHL, U .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (16) :5924-5928

[9] Coagulation-dependent inhibition of fibrinolysis: Role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma [J].

Broze, GJ ;

Higuchi, DA .

BLOOD, 1996, 88 (10) :3815-3823

[10] Carboxypeptidase R is an inactivator of complement-derived inflammatory peptides and an inhibitor of fibrinolysis [J].

Campbell, W ;

Okada, N ;

Okada, H .

IMMUNOLOGICAL REVIEWS, 2001, 180 :162-167

← 1 2 3 4 5 6 7 8 9 10 →