Dense fibrillar collagen matrices for tissue repair

被引：37

作者：

Guille, Marie Madeleine Giraud ^{[1
]}

Helary, Christophe ^{[1
]}

Vigier, Sylvain ^{[1
]}

Nassif, Nadine ^{[1
]}

机构：

[1] Univ Paris 06, Ecole Prat Hautes Etud, CNRS UMR 7574, Lab Chim Mat Condensee Paris, F-75005 Paris, France

来源：

SOFT MATTER | 2010年 / 6卷 / 20期

关键词：

LIQUID CRYSTALLINITY; HUMAN-FIBROBLASTS; IN-VITRO; SKIN; BIOMATERIALS; BEHAVIOR; REGENERATION; COMPRESSION; SUBSTITUTES; SCAFFOLDS;

D O I：

10.1039/c0sm00260g

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The preparation of dense fibrillar collagen matrices, through a sol/gel transition at variable concentrations, offers routes to produce a range of simple, non toxic materials. Concentrated hydrogels entrapping cells show enhanced properties in terms of reduced contraction and enhanced cell proliferation. Dense fibrillar matrices attain tissue like mechanical properties and show ultrastructures described in connective tissues, namely liquid crystalline cholesteric geometries. Their colonization by cells and possible association with a mineral phase in a tissue like manner validate their use as biomimetic materials for regenerative medicine.

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收藏

页码：4963 / 4967

页数：5

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