Basophils Orchestrate Chronic Allergic Dermatitis and Protective Immunity against Helminths

被引：270

作者：

Ohnmacht, Caspar ^{[1
]}

Schwartz, Christian ^{[1
]}

Panzer, Marc ^{[1
]}

Schiedewitz, Isabel ^{[1
]}

Naumann, Ronald ^{[2
]}

Voehringer, David ^{[1
]}

机构：

[1] Univ Munich, Inst Immunol, D-80336 Munich, Germany

[2] MPI Mol Cell Biol & Genet, Transgen Core Facil, D-01307 Dresden, Germany

来源：

IMMUNITY | 2010年 / 33卷 / 03期

基金：

欧洲研究理事会;

关键词：

T-CELLS; DENDRITIC CELLS; TYPE-2; IMMUNITY; IL-4; PRODUCTION; IN-VIVO; EFFECTOR FUNCTION; TRANSGENIC MICE; HOMEOSTASIS; RECRUITMENT; EXPRESSION;

D O I：

10.1016/j.immuni.2010.08.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Basophils are associated with T helper 2 (Th2) cell-polarized immune responses such as allergic disorders or helminth infections. To directly address the role of basophils for type 2 immunity, we generated transgenic mice with constitutive and selective deletion of basophils. Differentiation and accumulation of Th2 cells, induction of eosinophilia, and increase in serum IgE or IgG1 induced by allergens or by infection with the helminth Nippostrongylus brasiliensis appeared to be basophil independent. Further, basophils were not required for passive IgE- or IgG1-mediated systemic anaphylaxis. However, basophils were essential for IgE-meditated chronic allergic dermatitis and for protection against secondary infection with N. brasiliensis. These results demonstrate that basophils play an important role for protective immunity against helminths and orchestrate chronic allergic inflammation, whereas primary Th2 cell responses can operate efficiently in the absence of this cell type.

引用

收藏

页码：364 / 374

页数：11

相关论文

共 47 条

[11] Biology of Lung Dendritic Cells at the Origin of Asthma [J].

Lambrecht, Bart N. ;

Hammad, Hamida .

IMMUNITY, 2009, 31 (03) :412-424

[12] A highly efficient recombineering-based method for generating conditional knockout mutations [J].

Liu, PT ;

Jenkins, NA ;

Copeland, NG .

GENOME RESEARCH, 2003, 13 (03) :476-484

[13] IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites [J].

Liu, ZG ;

Liu, Q ;

Hamed, H ;

Anthony, RM ;

Foster, A ;

Finkelman, FD ;

Urban, JF ;

Gause, WC .

JOURNAL OF IMMUNOLOGY, 2005, 174 (04) :2242-2249

[14] Faithful activation of an extra-bright red fluorescent protein in "knock-in" Cre-reporter mice ideally suited for lineage tracing studies [J].

Luche, Herve ;

Weber, Odile ;

Rao, Tata Nageswara ;

Blum, Carmen ;

Fehling, Hans Joerg .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (01) :43-53

[15] A NEW ALLELE SASH (WSH) AT THE W-LOCUS AND A SPONTANEOUS RECESSIVE LETHAL IN MICE [J].

LYON, MF ;

GLENISTER, PH .

GENETICAL RESEARCH, 1982, 39 (03) :315-&

[16] Basophils, eosinophils, and mast cells in atopic and nonatopic asthma and in late-phase allergic reactions in the lung and skin [J].

Macfarlane, AJ ;

Kon, OM ;

Smith, SJ ;

Zeibecoglou, K ;

Khan, LN ;

Barata, LT ;

McEuen, AR ;

Buckley, MG ;

Walls, AF ;

Meng, Q ;

Humbert, M ;

Barnes, NC ;

Robinson, DS ;

Ying, S ;

Kay, AB .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 105 (01) :99-107

[17] Polyclonal and Specific Antibodies Mediate Protective Immunity against Enteric Helminth Infection [J].

McCoy, Kathy D. ;

Stoel, Maaike ;

Stettler, Rebecca ;

Merky, Patrick ;

Fink, Katja ;

Senn, Beatrice M. ;

Schaer, Corinne ;

Massacand, Joanna ;

Oderrnatt, Bernhard ;

Oettgen, Hans C. ;

Zinkernagel, Rolf M. ;

Bos, Nicolaas A. ;

Hengartner, Hans ;

Macpherson, Andrew J. ;

Harris, Nicola L. .

CELL HOST & MICROBE, 2008, 4 (04) :362-373

[18] Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite [J].

Min, B ;

Prout, M ;

Hu-Li, J ;

Zhu, JF ;

Jankovic, D ;

Morgan, ES ;

Urban, JF ;

Dvorak, AM ;

Finkelman, FD ;

LeGros, G ;

Paul, WE .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (04) :507-517

[19] Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter [J].

Mohrs, M ;

Shinkai, K ;

Mohrs, K ;

Locksley, RM .

IMMUNITY, 2001, 15 (02) :303-311

[20] Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells [J].

Mukai, K ;

Matsuoka, K ;

Taya, C ;

Suzuki, H ;

Yokozeki, H ;

Nishioka, K ;

Hirokawa, K ;

Etori, M ;

Yamashita, M ;

Kubota, T ;

Minegishi, Y ;

Yonekawa, H ;

Karasuyama, H .

IMMUNITY, 2005, 23 (02) :191-202

← 1 2 3 4 5 →