Synthesis and reactions of some new 5-carbonyl(4-amino-3-cyano-2-substituted thiophene-5-yl)-8-hydroxyquinoline (part II). Synthesis of thiazole; Isoxazole; Pyrazole, pyrimidine and pyridazine derivatives as possible antimicrobial agents

被引：14

作者：

Khalil, ZH

Yanni, AS

Gaber, AM

Abdel-Mohsen, SA ^{[2
]}

机构：

[1] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt

[2] Univ Hannover, Dept Organ Chem, D-30167 Hannover, Germany

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2000年 / 166卷

关键词：

synthesis of some new 5-carbonyl-(substituted thieno[2,3,b]thiophene)-8-hydroxyquinoline; derivatives; antimicrobial activity;

D O I：

10.1080/10426500008076531

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

5-Carbonyl-(3,4-diamino-2-ethylcarboxylatrthirno[2,3-b]thiophene-5yl)-8-hydroxyquinoline (1) reacts with various reagents to afford thiazole, oxadiazole, pyrazole, isoxazole, pyrimidine and pyridazine derivatives (2-13d). The structure of the compounds has been established by elemental analysis, IR, NMR and mass spectra. The compounds thus synthesized were screened for their antimicrobial activity.

引用

页码：57 / 69

页数：13

共 10 条

[1]

BAUER AW, 1966, AM J CLIN PATHOL, V45, P493

[2] ACTIVATED NITRILES IN HETEROCYCLIC SYNTHESIS - A NOVEL SYNTHESIS OF PYRAZOLO[1,5-A]PYRIMIDINES AND PYRANO[2,3-C]PYRAZOLES [J].