Ral GTPases and cancer: linchpin support of the tumorigenic platform

被引：175

作者：

Bodemann, Brian O. ^{[2
]}

White, Michael A. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Simmons Canc Ctr, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 02期

关键词：

D O I：

10.1038/nrc2296

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A confluence of recent observations has indicted the Ras-family G-proteins RALA and RALB as key offenders in the subversion of core biological systems driving oncogenic transformation. Here, we will focus on current developments highlighting the pivotal contribution of Ral proteins to the regulatory framework supporting tumorigenesis, and evaluate mechanistic connections between Ral effector activation and generation of this framework.

引用

页码：133 / 140

页数：8

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